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Qiang Zhang, Jennifer Collins, Athina Anastasaki, Dr. Russell Wallis, Dr. Daniel A. Mitchell, Dr. C. Remzi Becer and Prof. David M. Haddleton Sequence-Controlled Multi-Block Glycopolymers to Inhibit DC-SIGN-gp120 Binding Angewandte Chemie International Edition 52

Article first published online: 11 MAR 2013 | DOI: 10.1002/anie.201300068

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Chain of command: Multi-block glycopolymers made of mannose (M, see figure), glucose, and di(ethylene glycol) ethyl ether (D) monomers were synthesized using a technique to control the polymer sequence. These highly monodisperse glycopolymers were then tested for binding and inhibition of DC-SIGN, a protein important for HIV infection.

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