Mag. Markus Ruetz, Dr. Carmen Gherasim, Prof. Dr. Karl Gruber, Dr. Sergey Fedosov, Prof. Dr. Ruma Banerjee and Prof. Dr. Bernhard Kräutler Inside Cover: Access to Organometallic Arylcobaltcorrins through Radical Synthesis: 4-Ethylphenylcobalamin, a Potential “Antivitamin B12” (Angew. Chem. Int. Ed. 9/2013) Angewandte Chemie International Edition 52
An organometallic arylcobalamin is a “locked” form of vitamin B12 or “antivitamin B12”, and is accessible by a radical reaction, as reported by B. Kräutler et al. in their Communication on page 2606 ff. “Antivitamins B12” are novel molecular tools to induce functional vitamin B12 deficiency in laboratory animals. These studies may be helpful in clarifying controversial questions dealing with irreparable damage in the central and peripheral nervous system that is associated with vitamin B12 deficiency in humans.
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