Fahui Li, Pan Shi, Jiasong Li, Fan Yang, Tianyuan Wang, Wei Zhang, Feng Gao, Wei Ding, Dong Li, Juan Li, Ying Xiong, Jinpeng Sun, Weimin Gong, Changlin Tian and Jiangyun Wang A Genetically Encoded 19F NMR Probe for Tyrosine Phosphorylation Angewandte Chemie International Edition 52
Version of Record online: 28 FEB 2013 | DOI: 10.1002/anie.201300463
Simple and selective: Tyrosine phosphorylation is a pivotal post-translational modification which regulates the enzymatic activity, protein conformation, and protein–protein interactions. The highly efficient genetic incorporation of 3,5-difluorotyrosine (F2Y) in E. coli and the use of F2Y as a 19F NMR probe for the tyrosine phosphorylation are reported (see picture).
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