Dr. Yuan Zhang, Dr. Melissa L. Blackman, Dr. Andrew B. Leduc and Prof. Dr. Timothy F. Jamison Peptide Fragment Coupling Using a Continuous-Flow Photochemical Rearrangement of Nitrones Angewandte Chemie International Edition 52
Go with the flow: A general approach for amide bond formation by way of a continuous-flow photochemical rearrangement of nitrones was described (see scheme). Simple aryl-alkyl amide bonds as well as complex peptide bonds were constructed efficiently with a residence time less than 20 minutes. A tetrapeptide was synthesized in this way and the method could be applied to peptide fragment coupling.
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