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Sangsik Lee, Seunghee Oh, Aerin Yang, Jihyo Kim, Prof. Dieter Söll, Prof. Daeyoup Lee and Prof. Hee-Sung Park A Facile Strategy for Selective Incorporation of Phosphoserine into Histones Angewandte Chemie International Edition 52

Article first published online: 26 MAR 2013 | DOI: 10.1002/anie.201300531

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Phosphoserine incorporation: A general strategy for producing recombinant histones with site-specific serine phosphorylation is developed by engineering phosphoseryl-tRNA synthetase (SepRS) and elongation factor Tu (EF-Tu; see picture). Serine-phosphorylated nucleosomes provide direct evidence for crosstalk between phosphorylation and acetylation in histones.

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