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Dr. Dipankar Srimani, Yehoshoa Ben-David and Prof. Dr. David Milstein Direct Synthesis of Pyrroles by Dehydrogenative Coupling of β-Aminoalcohols with Secondary Alcohols Catalyzed by Ruthenium Pincer Complexes Angewandte Chemie International Edition 52

Version of Record online: 6 MAR 2013 | DOI: 10.1002/anie.201300574

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Pyrroles were synthesized in one step by using the acceptorless dehydrogenative coupling of amino alcohols with secondary alcohols (equivalent amounts), catalyzed by ruthenium pincer complexes (0.5 mol %) and a base (less than stoichiometric amounts) through selective C[BOND]N and C[BOND]C bond formation. This atom-economical, environmentally friendly methodology offers easy access to a range of substituted pyrroles in moderate to good yields.

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