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Yong Wang, Prof. Dr. Chao Chen, Jing Peng and Prof. Dr. Ming Li Copper(II)-Catalyzed Three-Component Cascade Annulation of Diaryliodoniums, Nitriles, and Alkynes: A Regioselective Synthesis of Multiply Substituted Quinolines Angewandte Chemie International Edition 52

Version of Record online: 9 APR 2013 | DOI: 10.1002/anie.201300586

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Three become one: Multiply substituted quinolines were synthesized from diaryliodoniums, alkynes, and nitriles by a CuII-catalyzed method. This cascade annulation is highly regioselective, step-economic, flexible with regard to the functional groups, and could potentially be applied to the synthesis of complex molecules.

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