Dr. Phaneendrasai Karri, Dr. Venkateshwarlu Punna, Dr. Keunsoo Kim and Prof. Dr. Ramanarayanan Krishnamurthy Base-Pairing Properties of a Structural Isomer of Glycerol Nucleic Acid Angewandte Chemie International Edition 52
Know your limit! IsoGNA (a structural isomer of GNA) was found—in sharp contrast to GNA—to be highly restricted in its ability to base-pair with itself and other nucleic acids. While homogeneous sequences (e.g. isoGNA(A)16) formed duplexes, the heterogeneous sequences showed no base-pairing. This exemplifies the limitations of canonical nucleobases as the recognition elements in simpler, more primitive phosphate backbones.
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