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Dr. Phaneendrasai Karri, Dr. Venkateshwarlu Punna, Dr. Keunsoo Kim and Prof. Dr. Ramanarayanan Krishnamurthy Base-Pairing Properties of a Structural Isomer of Glycerol Nucleic Acid Angewandte Chemie International Edition 52

Article first published online: 18 APR 2013 | DOI: 10.1002/anie.201300795

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Know your limit! IsoGNA (a structural isomer of GNA) was found—in sharp contrast to GNA—to be highly restricted in its ability to base-pair with itself and other nucleic acids. While homogeneous sequences (e.g. isoGNA(A)16) formed duplexes, the heterogeneous sequences showed no base-pairing. This exemplifies the limitations of canonical nucleobases as the recognition elements in simpler, more primitive phosphate backbones.

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