Youliang Wang, Akop Yepremyan, Dr. Subir Ghorai, Dr. Robert Todd, Prof. Dr. Donald H. Aue and Prof. Dr. Liming Zhang Gold-Catalyzed Cyclizations of cis-Enediynes: Insights into the Nature of Gold–Aryne Interactions Angewandte Chemie International Edition 52
Golden aryne? Gold aryne complexes are inferred as transition states in dual gold-catalyzed cyclizations of cis-enediynes (see scheme; DCE=1,2-dichloroethane). They are better described as ortho-aurophenyl cations, which react with weak nucleophiles and undergo facile intramolecular insertions into C(sp3)H bonds. Indanes, fused heteroarenes, and phenol derivatives are readily prepared using this method.
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