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Dr. Yu-Chun Lin, Yuta Nihongaki, Tzu-Yu Liu, Shiva Razavi, Prof. Moritoshi Sato and Prof. Takanari Inoue Rapidly Reversible Manipulation of Molecular Activity with Dual Chemical Dimerizers Angewandte Chemie International Edition 52

Version of Record online: 6 MAY 2013 | DOI: 10.1002/anie.201301219

Thumbnail image of graphical abstract

Tell it where to go: Rapamycin induced the relocation of an FRB-fused protein of interest (POI) to the plasma membrane (labeled with the fusion protein GAIs–FKBP–C2(LACT)) to activate a signaling event (see picture). Subsequent treatment with a gibberellic acid ester led to the relocation of the whole GAIs–FKBP–C2(LACT)/rapamycin/FRB–POI complex to the Tom20–GID1-labeled mitochondria with the termination of POI-dependent signaling.

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