Frauke Messik and Dr. Markus Oberthür Total Synthesis of the Antifungal Agent Echinocandin C Angewandte Chemie International Edition 52
Reliably stable: A dipeptide building block with fully elaborated N-acyl hemiaminal proved to be a versatile precursor for echinocandin C, a prototypical member of the echinocandin group of antimycotic drugs. This first total synthesis of an N-acyl hemiaminal-containing echinocandin is concise and highly convergent, thereby making additional derivatives easily accessible. PG=protecting group.
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