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Rebecca M. Wilson, Dr. Suwei Dong, Dr. Ping Wang and Prof. Samuel J. Danishefsky The Winding Pathway to Erythropoietin Along the Chemistry–Biology Frontier: A Success At Last Angewandte Chemie International Edition 52

Article first published online: 17 JUN 2013 | DOI: 10.1002/anie.201301666

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Going native: The total synthesis of a homogeneous erythropoietin, possessing the native amino acid sequence and chitobiose glycans at each of the three wild-type sites of N glycosylation, has been accomplished. Herein is an account of the decade-long research effort en route to this formidable target compound.

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