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Dr. Judit Tulla-Puche, Dr. Miriam Góngora-Benítez, Dr. Núria Bayó-Puxan, Dr. Andrés M. Francesch, Dr. Carmen Cuevas and Prof. Fernando Albericio Enzyme-Labile Protecting Groups for the Synthesis of Natural Products: Solid-Phase Synthesis of Thiocoraline Angewandte Chemie International Edition 52

Version of Record online: 25 APR 2013 | DOI: 10.1002/anie.201301708

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Another (orthogonal) dimension: The solid-phase synthesis of thiocoraline was accomplished for the first time by a combined approach involving chemical and enzymatic methods. One-pot cleavage of the phenylacetamidomethyl protecting group using immobilized penicillin G acylase enzyme (see picture) and disulfide formation are the key steps of the synthetic strategy.

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