Hsueh-Ying Chen, Mukundan Ragavan and Prof. Dr. Christian Hilty Protein Folding Studied by Dissolution Dynamic Nuclear Polarization Angewandte Chemie International Edition 52
Folding and hyperpolarization: A method is presented for the measurement of protein folding by nuclear magnetic resonance. Denatured polypeptide is hyperpolarized using dissolution dynamic nuclear polarization, yielding a substantial signal enhancement that allows real-time 13C NMR spectroscopy of the refolding process after a rapid pH jump. The resulting spectra indicate global and site-specific changes in the protein.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf