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Hsueh-Ying Chen, Mukundan Ragavan and Prof. Dr. Christian Hilty Protein Folding Studied by Dissolution Dynamic Nuclear Polarization Angewandte Chemie International Edition 52

Version of Record online: 15 JUL 2013 | DOI: 10.1002/anie.201301851

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Folding and hyperpolarization: A method is presented for the measurement of protein folding by nuclear magnetic resonance. Denatured polypeptide is hyperpolarized using dissolution dynamic nuclear polarization, yielding a substantial signal enhancement that allows real-time 13C NMR spectroscopy of the refolding process after a rapid pH jump. The resulting spectra indicate global and site-specific changes in the protein.

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