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Hunter P. Shunatona, Natalja Früh, Yi-Ming Wang, Dr. Vivek Rauniyar and Prof. Dr. F. Dean Toste Enantioselective Fluoroamination: 1,4-Addition to Conjugated Dienes Using Anionic Phase-Transfer Catalysis Angewandte Chemie International Edition 52

Version of Record online: 13 JUN 2013 | DOI: 10.1002/anie.201302002

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Chiral-anion phase-transfer catalysis (PTC) has been applied towards the enantioselective fluorocyclization reactions of 1,3-dienes. The method affords unprecedented fluorinated benz[f]isoquinoline and octahydroisoquinoline products in high yields and up to 96 % ee. New fluorinated amine reagents outperformed Selectfluor in the desired transformation.

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