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Dr. Gregory L. Beutner and Prof. Dr. Scott E. Denmark Lewis Base Catalysis of the Mukaiyama Directed Aldol Reaction: 40 Years of Inspiration and Advances Angewandte Chemie International Edition 52

Article first published online: 10 JUL 2013 | DOI: 10.1002/anie.201302084

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Aldol evergreen: Since the landmark publication of the first directed aldol addition reaction in 1973, the site, diastereo-, and enantioselective reaction has been elevated to the rarefied status of being both a named and a strategy-level reaction. The challenges of merging site, diastereo-, and enantioselectivity with catalysis into a unified reaction manifold have stimulated the development of Lewis base catalyzed aldol addition reactions.

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