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Chia-Hung Wang, Shiou-Ting Li, Tzu-Lung Lin, Yang-Yu Cheng, Dr. Tsung-Hsien Sun, Prof. Jin-Town Wang, Dr. Ting-Jen R. Cheng, Prof. Kwok Kong Tony Mong, Prof. Chi-Huey Wong and Prof. Chung-Yi Wu Synthesis of Neisseria meningitidis Serogroup W135 Capsular Oligosaccharides for Immunogenicity Comparison and Vaccine Development Angewandte Chemie International Edition 52

Article first published online: 10 JUL 2013 | DOI: 10.1002/anie.201302540

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Sweetening the deal: N. meningitidis serogroup W135 capsular oligosaccharides were synthesized in lengths from disaccharides to decasaccharides. Sera from mice immunized with these oligosaccharide–protein conjugates were examined by a glycan microarray (see picture) and bactericidal assay for antibody specificity and the ability to kill bacteria.

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