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Dr. Kyoung Hwa Jang, Dr. Sang-Jip Nam, Dr. Jeffrey B. Locke, Christopher A. Kauffman, Deanna S. Beatty, Lauren A. Paul and Prof. Dr. William Fenical Anthracimycin, a Potent Anthrax Antibiotic from a Marine-Derived Actinomycete Angewandte Chemie International Edition 52

Article first published online: 17 JUN 2013 | DOI: 10.1002/anie.201302749

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Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria.

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