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Dr. Alastair A. Cant, Dr. Sue Champion, Dr. Rajiv Bhalla, Dr. Sally L. Pimlott and Dr. Andrew Sutherland Nickel-Mediated Radioiodination of Aryl and Heteroaryl Bromides: Rapid Synthesis of Tracers for SPECT Imaging Angewandte Chemie International Edition 52

Version of Record online: 18 JUN 2013 | DOI: 10.1002/anie.201302800

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Rapid and efficient radioiodination of aryl and heteroaryl bromides has been achieved using a nickel(0)-mediated halogen-exchange reaction. This transformation gives direct access to [123I]- and [125I]-imaging agents for single photon emission computed tomography (SPECT), such as 5-[123I]-A85380 (see scheme, Boc=tert-butyloxycarbonyl, cod=1,5-cyclooctadiene, TFA=trifluoroacetic acid).

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