Xiao-Hui Yang, Prof. Jian-Hua Xie, Wei-Peng Liu and Prof. Qi-Lin Zhou Catalytic Asymmetric Hydrogenation of δ-Ketoesters: Highly Efficient Approach to Chiral 1,5-Diols Angewandte Chemie International Edition 52
High turnover: An highly efficient catalytic asymmetric hydrogenation of δ-aryl-δ-ketoesters has been realized by using the chiral spiroiridium catalyst (R)-1. Chiral 1,5-diol products are obtained with excellent enantioselectivity and turnover numbers (TONs) as high as 100 000. TOF=turnover frequency.
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