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Jakob Franke, Dr. Keishi Ishida, Dr. Mie Ishida-Ito and Prof. Dr. Christian Hertweck Nitro versus Hydroxamate in Siderophores of Pathogenic Bacteria: Effect of Missing Hydroxylamine Protection in Malleobactin Biosynthesis Angewandte Chemie International Edition 52

Article first published online: 2 JUL 2013 | DOI: 10.1002/anie.201303196

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The elusive structure of malleobactin, a virulence factor of pathogens belonging to the Burkholderia mallei family, was finally unveiled by genetic and chemical analyses. The novel nitro-substituted siderophore is derived from an unusual, unprotected hydroxylamine, which undergoes spontaneous oxidation, as shown by in vitro assays and detection of analogues featuring hydroxylamino, nitroso, and azoxide groups.

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