Dr. Richard J. Hopkinson, Louise J. Walport, Dr. Martin Münzel, Dr. Nathan R. Rose, Tristan J. Smart, Dr. Akane Kawamura, Dr. Timothy D. W. Claridge and Prof. Christopher J. Schofield Is JmjC Oxygenase Catalysis Limited to Demethylation? Angewandte Chemie International Edition 52
Jobs on the side: Substrate selectivity studies indicate that members of the biomedically important JmjC demethylase family of histone Nε-methyllysine demethylases are capable of catalyzing the de-N-alkylation of groups other than N-methyl and can catalyze reactions that form stable hydroxylated products. The differences in binding preferences in this set of enzymes may be helpful in the design of selective inhibitors.
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