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Kohei Sato, Prof. Dr. Akira Shigenaga, Keisuke Kitakaze, Ken Sakamoto, Prof. Dr. Daisuke Tsuji, Prof. Dr. Kohji Itoh and Prof. Dr. Akira Otaka Chemical Synthesis of Biologically Active Monoglycosylated GM2-Activator Protein Analogue Using N-Sulfanylethylanilide Peptide Angewandte Chemie International Edition 52

Article first published online: 13 JUN 2013 | DOI: 10.1002/anie.201303390

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Going to SEA(lide): Total chemical synthesis of a 162-residue glycoprotein analogue of the monoglycosylated human GM2-activator protein (GM2AP) was achieved. Key steps were the use of N-sulfanylethylanilide (SEAlide) peptides in the kinetic chemical ligation synthesis of a large peptide fragment, and a convergent native chemical ligation for final fragment assembly.

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