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Dr. Bin Shen, Dr. Jongho Jeon, Dr. Mikael Palner, Dr. Deju Ye, Dr. Adam Shuhendler, Prof. Frederick T. Chin and Prof. Jianghong Rao Positron Emission Tomography Imaging of Drug-Induced Tumor Apoptosis with a Caspase-Triggered Nanoaggregation Probe Angewandte Chemie International Edition 52

Article first published online: 23 JUL 2013 | DOI: 10.1002/anie.201303422

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Drug Design: An 18F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the 18F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).

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