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Dr. S. B. Jennifer Kan, Kenneth K.-H. Ng and Prof. Dr. Ian Paterson The Impact of the Mukaiyama Aldol Reaction in Total Synthesis Angewandte Chemie International Edition 52

Article first published online: 26 JUL 2013 | DOI: 10.1002/anie.201303914

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Four decades since Mukaiyama's first reports on the use of silicon and boron enolates in directed aldol reactions, this highly controlled carbon–carbon bond-forming method has been developed into a powerful tool for natural product synthesis. A number of representative total syntheses that demonstrate the impact of the Mukaiyama aldol reaction are described and the underlying mechanistic rationale that determines the stereochemical outcomes is discussed.

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