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Stephen T. Chau, J. Patrick Lutz, Kevin Wu and Prof. Abigail G. Doyle Nickel-Catalyzed Enantioselective Arylation of Pyridinium Ions: Harnessing an Iminium Ion Activation Mode Angewandte Chemie International Edition 52

Version of Record online: 10 JUL 2013 | DOI: 10.1002/anie.201303994

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A nickel for your thoughts … An enantioselective nickel-catalyzed cross-coupling between N-acylpyridinium salts and organozinc reagents is reported. The catalytic system, which is comprised of an air-stable NiII source and a chiral phosphoramidite ligand, affords 2-substituted-2,3-dihydro-4-pyridones with up to >99 % ee.

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