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Dr. Yizhong Wang, Dr. Chao Wang, Dr. John R. Butler and Prof. Joseph M. Ready Dehydrogenative Coupling to Enable the Enantioselective Total Synthesis of (−)-Simaomicin α Angewandte Chemie International Edition 52

Article first published online: 22 AUG 2013 | DOI: 10.1002/anie.201304812

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The anticancer natural product simaomicin α has been synthesized. Asymmetric synthesis allowed the assignment of absolute stereochemistry. The enantiomer of the naturally occurring substance shows potent cytotoxicity towards Gram-positive bacteria and human cancer cells. Bn=benzyl, BOM=benzyloxymethyl.

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