Dr. Bartlomiej Krawczyk, Eric F. van Herwerden, Prof. Dr. Herman S. Overkleeft and Prof. Dr. Roderich D. Süssmuth Elimination Reactions of Esters in the Biosynthesis of Polyketides and Ribosomal Peptides Angewandte Chemie International Edition 52
Enoyl intermediates are normally obtained through β-elimination of β-hydroxy carbonyl compounds. The OH group is eliminated either directly or is first activated through phosphorylation. Alternative strategies have now been identified: Glutamination or acetylation of a β-hydroxycarbonyl compound followed by β-elimination of an ester was proven to be a key step in the biosynthesis of class I lantipeptide and tetronate antibiotics.
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