Salvatore Mascia, Patrick L. Heider, Haitao Zhang, Richard Lakerveld, Brahim Benyahia, Paul I. Barton, Richard D. Braatz, Charles L. Cooney, James M. B. Evans, Timothy F. Jamison, Klavs F. Jensen, Allan S. Myerson and Bernhardt L. Trout End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation Angewandte Chemie International Edition 52
Version of Record online: 2 OCT 2013 | DOI: 10.1002/anie.201305429
A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.
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