E-mail a Wiley Online Library Link

Yan Yan, Dr. Jing Chen, Lihan Zhang, Qingfei Zheng, Ying Han, Hua Zhang, Daozhong Zhang, Prof. Dr. Takayoshi Awakawa, Prof. Dr. Ikuro Abe and Prof. Dr. Wen Liu Multiplexing of Combinatorial Chemistry in Antimycin Biosynthesis: Expansion of Molecular Diversity and Utility Angewandte Chemie International Edition 52

Article first published online: 2 OCT 2013 | DOI: 10.1002/anie.201305569

Thumbnail image of graphical abstract

Diversity-oriented biosynthesis of a library of antimycin-like compounds (380 altogether) was accomplished by using multiplex combinatorial biosynthesis. The core strategy depends on the use of combinatorial chemistry at different biosynthetic stages. This approach is applicable for the diversification of polyketides, nonribosomal peptides, and the hybrids that share a similar biosynthetic logic.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.