Yan Yan, Dr. Jing Chen, Lihan Zhang, Qingfei Zheng, Ying Han, Hua Zhang, Daozhong Zhang, Prof. Dr. Takayoshi Awakawa, Prof. Dr. Ikuro Abe and Prof. Dr. Wen Liu Multiplexing of Combinatorial Chemistry in Antimycin Biosynthesis: Expansion of Molecular Diversity and Utility Angewandte Chemie International Edition 52
Diversity-oriented biosynthesis of a library of antimycin-like compounds (380 altogether) was accomplished by using multiplex combinatorial biosynthesis. The core strategy depends on the use of combinatorial chemistry at different biosynthetic stages. This approach is applicable for the diversification of polyketides, nonribosomal peptides, and the hybrids that share a similar biosynthetic logic.
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