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Dr. Bin Shen, Dr. Jongho Jeon, Dr. Mikael Palner, Dr. Deju Ye, Dr. Adam Shuhendler, Prof. Frederick T. Chin and Prof. Jianghong Rao Inside Cover: Positron Emission Tomography Imaging of Drug-Induced Tumor Apoptosis with a Caspase-Triggered Nanoaggregation Probe (Angew. Chem. Int. Ed. 40/2013) Angewandte Chemie International Edition 52

Version of Record online: 20 AUG 2013 | DOI: 10.1002/anie.201306442

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The caspase-3 activity in doxorubicin-treated tumor xenografts is studied by positron emission tomography (PET) using a novel 18F-labeled caspase-3-sensitive nanoaggregation tracer. In their Communication on page 10511 ff., J. Rao, F. T. Chin, et al. show that the enzyme-activatable tracer improves the PET imaging of apoptotic tumors by intramolecular macrocyclization and in situ aggregation of the cyclized tracer upon caspase-3 activation. (Picture: Jim Strommer and Lydia-Marie Joubert.)

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