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Dr. Markus J. Bröcker, Joanne M. L. Ho, Prof. George M. Church, Prof. Dieter Söll and Prof. Patrick O'Donoghue Recoding the Genetic Code with Selenocysteine Angewandte Chemie International Edition 53

Article first published online: 25 NOV 2013 | DOI: 10.1002/anie.201308584

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The selenocysteine insertion machinery was engineered to recode multiple sense codons. This was demonstrated for Escherichia coli formate dehydrogenase and recombinant human thioredoxin reductase. In the picture the canonical genetic code table is overlaid with a single assay in which purple-colored cells express active Sec-containing enzymes.

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