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Dr. Zhi He and Prof. Dr. Timothy F. Jamison Continuous-Flow Synthesis of Functionalized Phenols by Aerobic Oxidation of Grignard Reagents Angewandte Chemie International Edition 53

Article first published online: 19 FEB 2014 | DOI: 10.1002/anie.201310572

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Putting on airs: Aerobic oxidation of (hetero)aryl Grignard reagents using compressed air proceeds with a gas-liquid continuous-flow system, thus enabling preparation of fucntionalized phenols. By integrating an in-line generation of ArMgBr intermediates with the aerobic oxidation, ortho-functionalized phenols can be assembled. The method demonstrates good functional-group (FG) compatibility, mild reaction conditions, and short reaction times.

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