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Dr. Yang Yang, Christopher W. Haskins, Wandi Zhang, Pui Leng Low and Prof. Dr. Mingji Dai Divergent Total Syntheses of Lyconadins A and C Angewandte Chemie International Edition 53

Article first published online: 5 MAR 2014 | DOI: 10.1002/anie.201400416

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Like-a-podium: Divergent total syntheses of the two Lycopodium alkaloids lyconadins A and C were developed from the intermediate 1. The synthesis of lyconadin A features a highly efficient ketal removal/formal aza-[4+2] cyclization to form the core structure. A ketal removal/Mannich reaction was used to construct the core structure of lyconadin C. The concise and flexible synthetic route offers a platform for the development of anti-neurodegenerative agents.

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