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Nanxi Wang, Dr. Yue Li, Dr. Wei Niu, Dr. Ming Sun, Dr. Ronald Cerny, Prof. Qingsheng Li and Prof. Jiantao Guo Construction of a Live-Attenuated HIV-1 Vaccine through Genetic Code Expansion Angewandte Chemie International Edition 53

Version of Record online: 8 APR 2014 | DOI: 10.1002/anie.201402092

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Combat against AIDS: A novel unnatural amino acid (UAA*)-mediated amber codon (UAG) suppression strategy was used to precisely control HIV-1 viability in vitro (see picture). The resulting live-attenuated virus can be potentially used as HIV-1 vaccine.

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