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Tae-Kyung Yu, Seung-A Shin, Eun-Hee Kim, Dr. Sunghyun Kim, Dr. Kyung-Seok Ryu, Dr. Haekap Cheong, Prof. Dr. Hee-Chul Ahn, Prof. Dr. Sangyong Jon and Prof. Dr. Jeong-Yong Suh An Unusual Protein–Protein Interaction through Coupled Unfolding and Binding Angewandte Chemie International Edition 53

Version of Record online: 1 JUL 2014 | DOI: 10.1002/anie.201404750

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Unfold and hold: It is known that protein–protein interactions can involve coupled folding and binding, but coupled unfolding and binding is not well characterized. An unusual protein–protein interaction is described in which the binding of an aptide (APT) to fibronectin extradomain B (EDB) involves partial unfolding to expose the binding surface. The structural and energetic details were determined by NMR spectroscopy and thermodynamic analysis.

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