Yoshihiro Sohtome, Nobuko Takemura, Keisuke Takada, Rika Takagi, Toshitsugu Iguchi and Kazuo Nagasawa Organocatalytic Asymmetric Nitroaldol Reaction: Cooperative Effects of Guanidine and Thiourea Functional Groups Chemistry – An Asian Journal 2
Helping each other: The guanidine–thiourea heterobifunctional compound 1 catalyzes diastereo- and enantioselective nitroaldol reactions at a chiral reaction interface. Addition of KI is crucial for inhibiting the retro-nitroaldol reaction and achieving high asymmetric induction. Bn=benzyl.
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