Martin Kesselgruber, Matthias Lotz, Pierre Martin, Gianpietro Melone, Markus Müller, Benoît Pugin, Frédéric Naud, Felix Spindler, Marc Thommen, Paul Zbinden and Hans-Ulrich Blaser Solphos: A New Family of Efficient Biaryl Diphosphine Ligands Chemistry – An Asian Journal 3
Effective for Ru-catalyzed hydrogenation: Solphos is a new modular atropisomeric biaryl ligand with an attractive activity profile. Very good catalytic performances have been demonstrated for the Ru-catalyzed hydrogenation of β-keto esters (95–99 % ee, s/c up to 100 000), of acetyl acetone (>99 % ee, dl/meso>98:2), and of an exocyclic α,β-unsaturated acid (98.6 % ee, s/c 250). In several cases, the nature of the PAr2 moiety has a significant effect on the enantioselectivity.
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