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Dr. Hong-Ying Niu, Dr. Chao Xia, Prof. Gui-Rong Qu, Shan Wu, Yi Jiang, Xin Jin and Prof. Dr. Hai-Ming Guo Microwave-Promoted “One-Pot” Synthesis of 4-Nitrobenzylthioinosine Analogues Using Thiourea as a Sulfur Precursor Chemistry – An Asian Journal 7

Version of Record online: 14 OCT 2011 | DOI: 10.1002/asia.201100699

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An efficient one-pot method for the synthesis of various C6-alkylthio-substituted purine nucleosides has been developed under microwave irradiation with good to excellent yields without any metal catalyst (see scheme). This process expands the scope of existing synthetic methodologies and was further successfully applied for synthesis of the biologically important compound 4-nitrobenzylthioinosine (NBTI).

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