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Carlos López, Elena Sanna, Lucas Carreras, Manel Vega, Prof. Carmen Rotger and Prof. Antoni Costa Molecular Recognition of Zwitterions: Enhanced Binding and Selective Recognition of Miltefosine by a Squaramide-Based Host Chemistry – An Asian Journal 8

Version of Record online: 5 NOV 2012 | DOI: 10.1002/asia.201200881

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The importance of a synergic combination between electrostatic and hydrogen-bonding interactions has been demonstrated. A self-complementary amidosquarate-squaramide host for miltefosine has been disclosed. In DMSO, this rather structurally simple host exhibits high affinity and enhanced selectivity for miltefosine owing to the goal-keeping effect of the amidosquarate unit.

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