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Cong-Bin Ji, Zhong-Yan Cao, Prof. Dr. Xin Wang, Prof. Dr. De-Yin Wu and Prof. Dr. Jian Zhou A Catalyst-Free, One-Pot Three-Component Aminomethylation of α-Substituted Nitroacetates: Theoretical and Experimental Studies into the Rate-Accelerating Effects of the Solvent Methanol Chemistry – An Asian Journal 8

Version of Record online: 5 MAR 2013 | DOI: 10.1002/asia.201300053

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3, 2, 1 go! An unprecedented one-pot, catalyst-free, three-component aminomethylation of α-substituted nitroacetates, formalin, and amines has been reported, thereby enabling the highly efficient synthesis of α,β-diamino acid precursors with great structural diversity.

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