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Jing Li, Guo-Liang Liu, Xian-He Zhao, Ji-Yuan Du, Hu Qu, Wen-Dao Chu, Ming Ding, Cong-Yang Jin, Meng-Xue Wei and Prof. Dr. Chun-An Fan Formal Synthesis of (±)-Morphine Chemistry – An Asian Journal 8

Version of Record online: 18 MAR 2013 | DOI: 10.1002/asia.201300139

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The pain ends here: A novel synthetic strategy for the construction of (±)-morphine rings B and E was developed, in which SmI2-promoted reductive coupling/desulfurization and tandem alcoholysis/oxa-Michael addition featured as the key steps for the assembly of the C9[BOND]C14 and C5[BOND]O bonds, respectively. Asymmetric tandem alcoholysis/oxa-Michael addition was also feasible for the enantiocontrolled synthesis of morphine.

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