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Jaakko L. O. Pohjoismäki and Steffi Goffart Of circles, forks and humanity: Topological organisation and replication of mammalian mitochondrial DNA BioEssays 33

Article first published online: 2 FEB 2011 | DOI: 10.1002/bies.201000137

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As the organisation of mitochondrial DNA is rather complex (ranging from supercoiled monomeric circles to catenanes and multimeric networks) it is not surprising that there are at least two different mechanisms of replication: a unidirectional, strand-asynchronous mode (RITOLS=RNA intermediates throughout the lagging strand) and a bi-directional strand-coupled mode (COSCOFA=conventional strand-coupled Okazaki-fragment associating).

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