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Mauro DiNuzzo, Bruno Maraviglia and Federico Giove Why does the brain (not) have glycogen? BioEssays 33

Article first published online: 21 FEB 2011 | DOI: 10.1002/bies.201000151

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Brain glycogen is a critical determinant in the modulation of carbohydrate supply at the cellular level. Increased neuronal firing might stimulate K+ induced, AMP-mediated glycogen mobilisation in astrocytes and production of hexose phosphates. These compounds, in turn, suppress hexokinase activity and thus reduce glucose uptake by astrocytes which saves extracellular blood-borne glucose for neuronal utilisation.

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