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Nick Lane Mitonuclear match: Optimizing fitness and fertility over generations drives ageing within generations BioEssays 33

Version of Record online: 16 SEP 2011 | DOI: 10.1002/bies.201100051

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In eukaryotic cells, coadaptation of mitochondrial and nuclear genomes may be behind the origin of two sexes, and dictate fertility, speciation, and adaptability in youth. The benefits, however, entail costs later in life: faster ageing and more age-related diseases.

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