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William A. McEwan, Donna L. Mallery, David A. Rhodes, John Trowsdale and Leo C. James Intracellular antibody-mediated immunity and the role of TRIM21 BioEssays 33

Version of Record online: 29 AUG 2011 | DOI: 10.1002/bies.201100093

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It was discovered recently that antibodies not only act outside of cells but that they can also enter cells to mediate an intracellular immune response by binding to the intracellular antibody receptor TRIM21, which then directs antibody-covered virions to the ubiquitin-proteasome system for degradation.

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