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Zhiwei Wang, Hidefumi Fukushima, Daming Gao, Hiroyuki Inuzuka, Lixin Wan, Alan W. Lau, Pengda Liu and Wenyi Wei The two faces of FBW7 in cancer drug resistance BioEssays 33

Version of Record online: 30 AUG 2011 | DOI: 10.1002/bies.201100101

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The ubiquitin ligase FBW7 acts as a tumor suppressor by targeting various oncogenic proteins for ubiquitination. Furthermore, loss of FBW7 is linked to drug resistance and this protein may therefore represent a novel therapeutic target to increase drug sensitivity of cancer cells to conventional chemotherapies.

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