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Daniel Ackerman and David Gems The mystery of C. elegans aging: An emerging role for fat BioEssays 34

Version of Record online: 27 FEB 2012 | DOI: 10.1002/bies.201100189

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Recent studies suggest that changes in lipid composition (and not total lipid levels) may retard aging in C. elegans. Furthermore, ectopic accumulation of fat in aging worms may cause lipotoxic effects, contributing to the age-related decline in tissue function.

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