Jens Przybilla, Joerg Galle and Thimo Rohlf Is adult stem cell aging driven by conflicting modes of chromatin remodeling? BioEssays 34
We hypothesize that age-related changes of chromatin structure originate in the limited cellular capability to inherit epigenetic information. Spontaneous loss of histone modification, e.g., during replication gives rise to changes in DNA methylation and accordingly in gene expression, manifesting a conflict between stem cell plasticity and long term gene silencing.
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