E-mail a Wiley Online Library Link

Jens Przybilla, Joerg Galle and Thimo Rohlf Is adult stem cell aging driven by conflicting modes of chromatin remodeling? BioEssays 34

Version of Record online: 23 JUL 2012 | DOI: 10.1002/bies.201100190

Thumbnail image of graphical abstract

We hypothesize that age-related changes of chromatin structure originate in the limited cellular capability to inherit epigenetic information. Spontaneous loss of histone modification, e.g., during replication gives rise to changes in DNA methylation and accordingly in gene expression, manifesting a conflict between stem cell plasticity and long term gene silencing.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field