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Montserrat Soler-López, Nahuai Badiola, Andreas Zanzoni and Patrick Aloy Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction BioEssays 34

Article first published online: 19 APR 2012 | DOI: 10.1002/bies.201100193

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The signal transduction mediator ECSIT (evolutionarily conserved signaling intermediate in Toll pathway) may act as an early pathogenic sensor in Alzheimer's disease, integrating multiple signaling inputs to generate precise cellular responses in a temporal/spatial pattern, which were — individually — already known to be involved in the disease.

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